Tumor suppressor function of Rab25 in triple-negative breast cancer
نویسندگان
چکیده
منابع مشابه
Tumor and Stem Cell Biology Identification of New Tumor Suppressor Genes in Triple-Negative Breast Cancer
Although genomic sequencing has provided a better understating of the genetic landmarks in triple-negative breast cancer (TNBC), functional validation of candidate cancer genes (CCG) remains unsolved. In this study, we used a transposon mutagenesis strategy based on a two-step sleeping beauty (SB) forward genetic screen to identify and validate new tumor suppressors (TS) in this disease. We gen...
متن کاملUncovering a Tumor Suppressor for Triple-Negative Breast Cancers
"Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.
متن کاملClinicopathological Features of Non-metastatic Triple Negative Breast Cancer
Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based ...
متن کاملTumor suppressor role of microRNA-1296 in triple-negative breast cancer
UNLABELLED Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis, which lacks effective targeted therapies. There is an urgent need to better understand the underlying molecular mechanisms of TNBC aggressiveness and identify novel, efficient targets for therapeutic intervention. METHODS miRNA qRT-PCR was used to determine the expression of miR-12...
متن کاملIdentification of new tumor suppressor genes in triple-negative breast cancer.
Although genomic sequencing has provided a better understating of the genetic landmarks in triple-negative breast cancer (TNBC), functional validation of candidate cancer genes (CCG) remains unsolved. In this study, we used a transposon mutagenesis strategy based on a two-step Sleeping Beauty (SB) forward genetic screen to identify and validate new tumor suppressors (TS) in this disease. We gen...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2010
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.24900